Altered Tropomyosin Expression in Essential Hypertension
نویسندگان
چکیده
منابع مشابه
Altered tropomyosin expression in essential hypertension.
Abnormal erythrocyte sodium-lithium countertransport is common in a subgroup of patients with essential hypertension and a strong family history of hypertension and cardiovascular disease. We have previously shown that the abnormality in sodium-lithium countertransport is associated with tropomyosin, a cytoskeletal protein required to stabilize actin filament formation. Leukocyte trafficking ev...
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We assessed whether large-scale expression profiling of leukocytes of patients with essential hypertension reflects characteristics of systemic disease and whether such changes are responsive to antihypertensive therapy. Total RNA from leukocytes were obtained from untreated (n=6) and treated (n=6) hypertensive patients without apparent end-organ damage and from normotensive controls (n=9). RNA...
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Fourteen patients with untreated mild to moderate essential hypertension had, on average, an abnormally high cardiovascular reactivity to exogenous noradrenaline and angiotensin II, while plasma noradrenaline, renin activity, exchangeable body sodium, and blood volume were normal. Treatment with a low dose of indapamide (2.5 mg/day) for 6 weeks decreased blood pressure by 10% in these hypertens...
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Aldosterone responsiveness to angiotensin II (A II) was evaluated in 64 subjects with "normal renin" hypertension. Plasma aldosterone (PA) and plasma renin activity (PRA) levels were determined with the subjects supine and after 2 72 hours in the upright position while they were in metabolic balance on a 10 mEq of sodium/100 mEq of potassium diet. The increment in PA between supine and upright ...
متن کاملDifferential regulation of tropomyosin isoform organization and gene expression in response to altered actin gene expression
Phenotypically altered C2 myoblast cells, generated by the stable transfection of human nonmuscle actin genes (Schevzov, G., C. Lloyd, and P. Gunning. 1992. J. Cell Biol. 117:775-786), exhibit a differential pattern of tropomyosin cellular organization and isoform gene expression. The beta-actin transfectants displaying a threefold increase in the cell surface area, showed no significant change...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2003
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.0000050646.79785.7c